nachr inhibitor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12165	nAChR agonist 1	DUN71755	AChR
	nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.		AChR
T8868	4BP-TQS		AChR
	4BP-TQS is an allosteric agonist of α7 nAChRs.		AChR
T9542	NS3861		AChR
	NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and bind with high affinity to heteromeric α3β4 and α4β2 nAChRs. NS3861 displays the β-subunit preference and a complete lack of activation at α4-contain...		AChR
T14094	Acetamiprid		AChR
	Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist. Acetamiprid is a neonicotinoid insecticide used worldwide. It is shown to be associated with neuromuscular and reproductive disorders.		AChR
T17300	(-)-(S)-B-973B		AChR
	(-)-(S)-B-973B is an effective allosteric agonist and a positive allosteric modulator of α7 nAChR.		AChR
T9076	Spinosad		Others
	Spinosad is a naturally-occurring insecticide found in the the soil bacterium S. spinosa. It is a mixture of the macrocyclic lactones spinosyn A and spinosyn D, which act as agonists of insect nicotinic acetylcholinester...		Others
T1594	Vecuronium bromide	ORG NC 45	AChR
	Vecuronium bromide (ORG NC 45) is a synthetic, intermediate-acting mono-quaternary steroid and non-depolarizing neuromuscular blocking agent, with muscle relaxant activity.		AChR
T2422	PNU-282987		AChR
	PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).		AChR
T7671	Myosmine		Others , AChR
	Myosmine is a minor tobacco alkaloid that is structurally related to nicotine.		Others , AChR
TQ0117	A-867744		AChR , Autophagy
	A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).		AChR , Autophagy
T7853	(+)-Sparteine	Pachycarpine	AChR
	(+)-Sparteine (Pachycarpine) is a natural product extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent		AChR
T9787	Suvn-911		AChR
	suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.		AChR
T37196	5-AAM-2-CP		AChR
	5-AAM-2-CP is one of the major metabolites of Acetamiprid. Acetamiprid, a nAChR agonist, is a neonicotinoid insecticide used worldwide.		AChR
T5S0994	N-Methylcytisine	Caulophylline	Others , AChR
	1. N-Methylcytisine (Caulophylline)'s nicotinic receptors have high affinity (KD = 5 nM)to nAChR from squid optical ganglia. 2. N-Methylcytisine and N, N-dimethylcytisine did not displace 14C-tubocurarine at a concentrat...		Others , AChR
T28199	NS9283	NS 9283,NS-9283	AChR
	NS9283 is a positive allosteric modulator of α4β2 receptor.		AChR
T7193	Encenicline	EVP-6124	AChR
	Encenicline (EVP-6124) is a selective α7 nicotinic acetylcholine receptor (nAChRs) agonist in development for treating cognitive impairment in schizophrenia and Alzheimer's disease.		AChR
T27624	Iptakalim Hydrochloride		Potassium Channel , AChR
	Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Iptakalim is also a K(ir) 6.1/SUR2...		Potassium Channel , AChR
T8552	PSEM 89S TFA		AChR
	PSEM 89S TFA is a brain-penetrant and selective ion channels agonist, and is orthogonally selective for Q79G and L141F, respectively.		AChR
TP2063	α-Conotoxin MII		AChR
	α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuro...		AChR
T4246	Varenicline dihydrochloride		AChR
	Varenicline dihydrochloride is a Selective α4β2 nicotinic acetylcholine receptor partial agonist.		AChR